Which organs are affected by Myacin antibiotics?

Which organs are affected by Myacin antibiotics?

• A. Lungs and liver
• B. Heart and kidneys
• C. Kidneys and ears (ototoxicity)
• D. Stomach and intestines

Answer: (C)

Aminoglycoside antibiotics are known for a toxicity pattern that hits two organs: the kidneys and the inner ear. They accumulate in renal proximal tubule cells, which can lead to nephrotoxicity, especially with prolonged therapy or contributing risk factors. They also accumulate in the hair cells of the cochlea and vestibular apparatus, causing ototoxicity that can result in hearing loss and balance problems. Because of this, the organs affected are the kidneys and the ears, making that pairing the best fit. The other options don’t reflect the classic toxicity: lungs and liver aren’t the typical targets, the heart isn’t usually affected by this drug class, and while GI upset can occur, these drugs are poorly absorbed orally and GI toxicity isn’t the defining issue.

Aminoglycoside antibiotics are known for a toxicity pattern that hits two organs: the kidneys and the inner ear. They accumulate in renal proximal tubule cells, which can lead to nephrotoxicity, especially with prolonged therapy or contributing risk factors. They also accumulate in the hair cells of the cochlea and vestibular apparatus, causing ototoxicity that can result in hearing loss and balance problems. Because of this, the organs affected are the kidneys and the ears, making that pairing the best fit. The other options don’t reflect the classic toxicity: lungs and liver aren’t the typical targets, the heart isn’t usually affected by this drug class, and while GI upset can occur, these drugs are poorly absorbed orally and GI toxicity isn’t the defining issue.